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Air pollution during the perinatal period and neurodevelopment in children: A national population study in Taiwan.
Shih, Ping; Chiang, Tung-Liang; Wu, Chih-Da; Shu, Bih-Ching; Lung, For-Wey; Guo, Yue Leon.
Afiliación
  • Shih P; Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Chiang TL; Department of Environmental and Occupational Medicine, National Taiwan University, Taipei, Taiwan.
  • Wu CD; Department of Environmental and Occupational Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
  • Shu BC; Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan.
  • Lung FW; Department of Geomatics, National Cheng Kung University, Tainan, Taiwan.
  • Guo YL; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Dev Med Child Neurol ; 65(6): 783-791, 2023 06.
Article en En | MEDLINE | ID: mdl-36349526
AIM: To evaluate the association between ambient particulate matter no larger than 2.5 µm in diameter (PM2.5 ) during the prenatal and postnatal periods and infant neurodevelopmental parameters. METHOD: We conducted a population-based birth cohort study using the Taiwan Birth Cohort Study. Participants were assessed for developmental conditions through home interviews at 6 months and 18 months of age. Exposure to PM2.5 of mothers and infants during perinatal periods was estimated using hybrid kriging/land-use regression. The exposure was linked to each participant by home address. Logistic regression was then conducted to determine the risk of neurodevelopmental delay in relation to PM2.5 . RESULTS: A total of 17 683 term singletons without congenital malformations were included in the final analysis. PM2.5 during the second trimester was associated with increased risks of delays in gross motor neurodevelopmental milestones (adjusted odds ratio [aOR] 1.09 per 10 µg/m3 increase in exposure to PM2.5 ). Delayed fine motor development was also found to be related to exposure to PM2.5 in the second and third trimesters (aOR 1.06), as was personal-social skill (aOR 1.11 for the second trimester and 1.06 for the third). These neurodevelopmental parameters were unrelated to postnatal PM2.5 exposure. INTERPRETATION: Exposure to ambient PM2.5 during pregnancy was significantly related to delay in gross motor, fine motor, and personal-social development in this population-based study. WHAT THIS PAPER ADDS: Prenatal exposure to higher PM2.5 was associated with increased risk of delayed early neurodevelopment. The critical period for delayed gross motor development was the second trimester. The critical period for fine motor and personal-social development was the second and third trimesters.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Desarrollo Infantil / Discapacidades del Desarrollo / Exposición Materna / Contaminantes Atmosféricos / Contaminación del Aire Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Infant / Male / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Dev Med Child Neurol Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Desarrollo Infantil / Discapacidades del Desarrollo / Exposición Materna / Contaminantes Atmosféricos / Contaminación del Aire Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Infant / Male / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Dev Med Child Neurol Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido