Mechanical Activation of Zero-Valent Metal Reductants for Nickel-Catalyzed Cross-Electrophile Coupling.
ACS Catal
; 12(21): 13681-13689, 2022 Nov 04.
Article
en En
| MEDLINE
| ID: mdl-36366760
ABSTRACT
The cross-electrophile coupling of either twisted-amides or heteroaryl halides with alkyl halides, enabled by ball-milling, is herein described. The operationally simple nickel-catalyzed process has no requirement for inert atmosphere or dry solvents and delivers the corresponding acylated or heteroarylated products across a broad range of substrates. Key to negating the necessity of inert reaction conditions is the mechanical activation of the raw metal terminal reductant manganese in the case of twisted amides and zinc for heteroaryl halides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
ACS Catal
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido