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Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain.
Mele-Casas, Maria; Launes, Cristian; de Sevilla, Mariona F; Hernandez-Garcia, Maria; Pons-Tomas, Gemma; Bassat, Quique; Fumado, Victoria; Fortuny, Claudia; Garcia-Miquel, Aleix; Bonet-Carne, Elisenda; Prats, Clara; Ajanovic, Sara; Cubells, Marta; Claverol, Joana; Penela-Sanchez, Daniel; Jou, Cristina; Arias, Sara; Balanza, Nuria; Baro, Barbara; Millat-Martinez, Pere; Alonso, Sergio; Alvarez-Lacalle, Enric; Catala, Marti; Cuadras, Daniel; Muñoz-Almagro, Carmen; Gratacos, Eduard; Jordan, Iolanda; Garcia-Garcia, Juan Jose.
Afiliación
  • Mele-Casas M; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Launes C; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • de Sevilla MF; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Hernandez-Garcia M; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Pons-Tomas G; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Bassat Q; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Fumado V; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Fortuny C; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Garcia-Miquel A; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Bonet-Carne E; Pediatric Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Prats C; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Ajanovic S; ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
  • Cubells M; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
  • Claverol J; ICREA, Pg. Lluís Companys 23, Barcelona, Spain.
  • Penela-Sanchez D; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Jou C; Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain.
  • Arias S; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Balanza N; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Baro B; Infectious Diseases Department, Hospital Sant Joan de Déu, Barcelona, Spain.
  • Millat-Martinez P; BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, Barcelona, Spain.
  • Alonso S; BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), University of Barcelona, Barcelona, Spain.
  • Alvarez-Lacalle E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Catala M; Universitat Politècnica de Catalunya, BarcelonaTech, Barcelona, Spain.
  • Cuadras D; Department of Physics, Computational Biology and Complex Systems (BIOCOM-SC), Universitat Politècnica de Catalunya, Castelldefels, Spain.
  • Muñoz-Almagro C; ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.
  • Gratacos E; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
  • Jordan I; Fundació Sant Joan de Déu, Barcelona, Spain.
  • Garcia-Garcia JJ; Institut de Recerca Sant Joan de Déu, University of Barcelona, Barcelona, Spain.
PLoS One ; 17(11): e0277754, 2022.
Article en En | MEDLINE | ID: mdl-36395194
ABSTRACT

BACKGROUND:

Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households.

METHODS:

A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated.

RESULTS:

1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01).

CONCLUSIONS:

Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Child / Humans País/Región como asunto: Europa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Child / Humans País/Región como asunto: Europa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: España