Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and &#945;-Bromo Carbonyl Compounds.

Zhang, Xiaoke; Wang, Haibo; Li, Ziwei; Shu, Yan; Gan, Song; Zhang, Xuefang; Shao, Huawu; Wang, Chaoyong

Chemodivergent Synthesis of Aza-Heterocycles with a Quarternary Carbon Center via [4 + 1] Annulation between Azoalkenes and α-Bromo Carbonyl Compounds.

Zhang, Xiaoke; Wang, Haibo; Li, Ziwei; Shu, Yan; Gan, Song; Zhang, Xuefang; Shao, Huawu; Wang, Chaoyong.

Afiliación

Zhang X; Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408000, P.R. China.
Wang H; Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Li Z; Zhejiang Hongyuan Pharmaceutical Co., Ltd., Chem & APIs, Industrial Zone, Linhai, Taizhou 310001, Zhejiang, P.R. China.
Shu Y; Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408000, P.R. China.
Gan S; Central Laboratory, Chongqing University FuLing Hospital, Chongqing 408000, P.R. China.
Zhang X; Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Shao H; Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Wang C; Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 100045, P.R. China.

ACS Omega ; 7(45): 40963-40972, 2022 Nov 15.

Article en En | MEDLINE | ID: mdl-36406503

ABSTRACT

ABSTRACT

An efficient [4 + 1] annulation reaction between in situ generated azoalkene intermediates and α-bromocarbonyls has been established. A series of skeletally diverse aza-heterocycles with a functionalized quaternary center were obtained in up to 89% yield under mild conditions.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Omega Año: 2022 Tipo del documento: Article