Ligand-free nickel catalyzed perfluoroalkylation of arenes and heteroarenes.
Chem Sci
; 13(44): 12971-12979, 2022 Nov 16.
Article
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| MEDLINE
| ID: mdl-36425484
ABSTRACT
We describe a "ligand-free" Ni-catalyzed perfluoroalkylation of heteroarenes to produce a diverse array of trfiluoromethyl, pentafluoroethyl and heptafluoropropyl adducts. Catalysis proceeds at room temperature via a radical pathway. The catalytic protocol is distinguished by its simplicity, and its wide scope demonstrates the potential in the late-stage functionalization of drug analogues and peptides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2022
Tipo del documento:
Article