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Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer's Disease: Dietary Plant Polyphenols.
Wang, Yi; Wang, Kaiyue; Yan, Junyuan; Zhou, Qian; Wang, Xiaoying.
Afiliación
  • Wang Y; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
  • Wang K; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
  • Yan J; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
  • Zhou Q; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
  • Wang X; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Int J Mol Sci ; 23(22)2022 Nov 11.
Article en En | MEDLINE | ID: mdl-36430365
Alzheimer's disease (AD) is an incurable degenerative disease of the central nervous system and the most common type of dementia in the elderly. Despite years of extensive research efforts, our understanding of the etiology and pathogenesis of AD is still highly limited. Nevertheless, several hypotheses related to risk factors for AD have been proposed. Moreover, plant-derived dietary polyphenols were also shown to exert protective effects against neurodegenerative diseases such as AD. In this review, we summarize the regulatory effects of the most well-known plant-derived dietary polyphenols on several AD-related molecular mechanisms, such as amelioration of oxidative stress injury, inhibition of aberrant glial cell activation to alleviate neuroinflammation, inhibition of the generation and promotion of the clearance of toxic amyloid-ß (Aß) plaques, inhibition of cholinesterase enzyme activity, and increase in acetylcholine levels in the brain. We also discuss the issue of bioavailability and the potential for improvement in this regard. This review is expected to encourage further research on the role of natural dietary plant polyphenols in the treatment of AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Enfermedad de Alzheimer Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza