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A dynamic reversible phenylboronic acid sensor for real-time determination of protein-carbohydrate interactions on living cancer cells.
Song, Quanquan; Li, Qian; Chao, Shuang; Chen, Xian; Li, Ronghui; Lu, Yuchao; Aastrup, Teodor; Pei, Zhichao.
Afiliación
  • Song Q; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Li Q; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Chao S; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Chen X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
  • Li R; Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism and College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, China. luyuchao@hebau.edu.cn.
  • Lu Y; Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism and College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, China. luyuchao@hebau.edu.cn.
  • Aastrup T; Attana, Stockholm SE-11419, Sweden.
  • Pei Z; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China. peizc@nwafu.edu.cn.
Chem Commun (Camb) ; 58(99): 13731-13734, 2022 Dec 13.
Article en En | MEDLINE | ID: mdl-36444745
ABSTRACT
Real-time detection of glycosylation on label-free cancer cell surfaces is of significance for the diagnosis and treatment of cancer. In this work, we have successfully developed a novel dynamic reversible sensor based on pH-sensitive phenylboronic esters to determine in real-time the binding kinetics of protein-carbohydrate interactions on suspension cancer cell surfaces using a quartz crystal microbalance (QCM) technique.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Neoplasias Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Neoplasias Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article