[Neurocognitive impairment and characteristics of neurocognitive performance among people with HIV on antiretroviral treatment].
Zhonghua Liu Xing Bing Xue Za Zhi
; 43(10): 1651-1657, 2022 Oct 10.
Article
en Zh
| MEDLINE
| ID: mdl-36456499
ABSTRACT
Objective:
Using two measuring tools to examine the prevalence and correlates of neurocognitive impairment (NCI) as well as characteristics of neurocognitive performance among people with HIV (PWH) on antiretroviral treatment (ART).Methods:
A total of 2 250 treated PWH from the Comparative HIV and Aging Research in Taizhou (CHART) were recruited in Taizhou, Zhejiang province. The Chinese version of the Mini-mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS) were used to evaluate their neurocognitive performance. Cluster analysis was conducted on the seven cognitive domains in the scale.Results:
Among 2 250 treated PWH, 48.0% (1 080/2 250) were aged 45 to 89, 79.2% (1 782/2 250) were male, and 37.8% (852/2 250) had primary school education or below. The prevalence of neurocognitive impairment judged by MMSE and IHDS among HIV-infected people was 14.3% (321/2 250) and 31.8% (716/2 250), respectively. Aged 60 to 89 (aOR=2.63, 95%CI1.52-4.56), depressive symptoms (aOR=5.58, 95%CI4.20-7.40) and treatment with EFV (aOR=2.86, 95%CI1.89-4.34) were main risk factors of NCI diagnosed by MMSE. Male (aOR=0.71, 95%CI0.51-1.00), overweight (aOR=0.63, 95%CI0.44-0.89), and high education level (aOR=0.11, 95%CI0.05-0.25) were protective factors of NCI diagnosed by MMSE. Aged 60 to 89 (aOR=3.10, 95%CI2.09-4.59), depressive symptoms (aOR=1.78, 95%CI1.44-2.20) and treatment with EFV (aOR=1.79, 95%CI1.41-2.29) were risk factors of NCI diagnosed by IHDS. Male (aOR=0.75, 95%CI0.58-0.97), underweight (aOR=0.67, 95%CI0.47-0.96), baseline CD4+ T lymphocyte (CD4) counts ≥350 cells/µl (aOR=0.69, 95%CI0.53-0.91) and high education level (aOR=0.23, 95%CI0.14-0.39) were protective factors of NCI diagnosed by IHDS. The neurocognitive performance of HIV-infected people can be divided into four main types. Among four types, age, gender, education level, alcohol drinking, depressive symptoms, waist-to-hip ratio, hypertension, diabetes, baseline CD4 counts and treatment with EFV were different statistically (all P<0.05).Conclusions:
There are four main types of neurocognitive performance in treated PWH. The prevalence of NCI is high among this population, underscoring the need for tailored prevention and intervention.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Antirretrovirales
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Liu Xing Bing Xue Za Zhi
Año:
2022
Tipo del documento:
Article
País de afiliación:
China