Pregnancy in homozygous familial hypercholesterolemia-A case series.
Ther Apher Dial
; 26 Suppl 1: 89-96, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36468316
ABSTRACT
INTRODUCTION:
Familial hypercholesterolemia (FH) is an autosomal codominant lipid metabolism disorder. It results in lifelong elevation of plasmatic low-density lipoprotein cholesterol (LDL-C) levels, followed by premature atherosclerosis. In women, pregnancy and lactation represent an additional risk due to association of physiological changes, pre-existing dyslipidemia, and limited therapeutic possibilities and experiences. Methods of extracorporeal LDL-apheresis represent a suitable therapeutic approach. CASE SERIES We present our experience in case reports of six HoFH women and their 13 pregnancies (nine successful, three abortions, and one interruption). One patient experienced a lethal complication of her pregnancy. Of the nine successful pregnancies, two cases were treated by LDL-apheresis.CONCLUSION:
Pregnancy in HoFH women represents substantial risk; however, patients without signs of decompensated cardiovascular disease can have a good prognosis. LDL-apheresis plays an important role in the management of pregnancy in HoFH.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Eliminación de Componentes Sanguíneos
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Enfermedades Cardiovasculares
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Aterosclerosis
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Hipercolesterolemia Familiar Homocigótica
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Hiperlipoproteinemia Tipo II
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Ther Apher Dial
Asunto de la revista:
HEMATOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
República Checa
Pais de publicación:
AU
/
AUSTRALIA
/
AUSTRÁLIA