Intraductal Carcinoma of the Prostate without High-Grade Invasive Adenocarcinoma: Report of Two Cases and Review of the Literature.
Arch Esp Urol
; 75(9): 738-745, 2022 Nov.
Article
en En
| MEDLINE
| ID: mdl-36472055
ABSTRACT
OBJECTIVES:
Intraductal carcinoma of the prostate (IDC-P) is usually associated with high grade, aggresive acinar adenocarcinomas. IDC-P is supposed to result from the spread of the adenocarcinoma along the prostatic ducts. IDC-P rarely occurs without invasive carcinoma or with a coexistent low grade adenocarcinoma. MATERIAL ANDMETHODS:
We report two patients, 66 and 75 year-old, who presented IDC-P and low-grade acinar adenocarcinoma foci in their radical prostatectomy surgical specimens.RESULTS:
Acinar adenocarcinomas were grade group 1, PTEN+, pT2. In the first case, the invasive adenocarcinoma was adjacent but nor intermingled with the IDC-P, and a discordance in the immunophenotype between them was outstanding (positivity for ERG in the acinar carcinoma being negative in the IDC-P). In the second case, the foci of adenocarcinoma were distant from the IDC-P. The first patient had not biochemical recurrence after a 34 month follow-up period.CONCLUSIONS:
This kind of cases supports the existence of an infrequent subtype of IDC-P that could be considered as an in situ neoplasia.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Adenocarcinoma
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Carcinoma Intraductal no Infiltrante
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Neoplasia Intraepitelial Prostática
Límite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Arch Esp Urol
Año:
2022
Tipo del documento:
Article