Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1.

Wada, Reona; Fujinuma, Shun; Nakatsumi, Hirokazu; Matsumoto, Masaki; Nakayama, Keiichi I

Wada, Reona; Fujinuma, Shun; Nakatsumi, Hirokazu; Matsumoto, Masaki; Nakayama, Keiichi I.

Afiliación

Wada R; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Fujinuma S; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Nakatsumi H; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Matsumoto M; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Nakayama KI; Department of Omics and Systems Biology, Graduate School of Medical and Dental Sciences, Niigata University, 757 Ichibancho, Asahimachi-dori, Chuo-ku, Niigata City, Niigata 951-8510, Japan.

J Biochem ; 173(2): 129-138, 2023 Feb 03.

Article en En | MEDLINE | ID: mdl-36477205

Asunto(s)

Glucógeno Sintasa Quinasa 3; Transducción de Señal; Diana Mecanicista del Complejo 1 de la Rapamicina/metabolismo; Glucógeno Sintasa Quinasa 3/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; Fosforilación; Proteína Fosfatasa 1/metabolismo

Palabras clave

glycogen synthase kinase 3 (GSK3) Abbreviations: DAPI, 4',6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; ERK, extracellular signalregulated kinase; FOXK1, forkhead box K1; GSK3, glycogen synthase kinase 3; HA, hemagglutinin; LARP1, La-related protein 1; MEK, ERK kinase; mTORC1, mechanistic target of rapamycin complex 1; PBS, phosphate-buffered saline; PBX2, preB cell leukemia transcription factor 2; PI3K, phosphoinositide 3-kinase; PDK1, phosphoinositide-dependent protein kinase 1; PP1, protein phosphatase 1; PP2A, protein phosphatase 2A; RAG, RAS-related GTP-binding protein; RHEB, Ras homolog enriched in Brain; shRNA, short hairpin RNA; siRNA, small interfering RNA; TBC1D7, TBC1 (TRE2-BUB2-CDC16) domain family member 7; TSC2, tuberous sclerosis complex 2; WT, wild-type; mechanistic target of rapamycin complex 1 (mTORC1); phosphorylation; preB cell leukemia transcription factor 2 (PBX2); protein phosphatase 1 (PP1)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Glucógeno Sintasa Quinasa 3 Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biochem Año: 2023 Tipo del documento: Article País de afiliación: Japón

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