The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors.

Ruiz-Cantero, M Carmen; Cortés-Montero, Elsa; Jain, Aakanksha; Montilla-García, Ángeles; Bravo-Caparrós, Inmaculada; Shim, Jaehoon; Sánchez-Blázquez, Pilar; Woolf, Clifford J; Baeyens, José M; Cobos, Enrique J

Ruiz-Cantero, M Carmen; Cortés-Montero, Elsa; Jain, Aakanksha; Montilla-García, Ángeles; Bravo-Caparrós, Inmaculada; Shim, Jaehoon; Sánchez-Blázquez, Pilar; Woolf, Clifford J; Baeyens, José M; Cobos, Enrique J.

Afiliación

Ruiz-Cantero MC; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.
Cortés-Montero E; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.
Jain A; Biosanitary Research Institute ibs. GRANADA, Granada, Spain.
Montilla-García Á; Department of Translational Neurosciences, Neuropharmacology, Cajal Institute, CSIC, Madrid, Spain.
Bravo-Caparrós I; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Shim J; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Sánchez-Blázquez P; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.
Woolf CJ; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.
Baeyens JM; Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain.
Cobos EJ; Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain.

Br J Pharmacol ; 180(8): 1148-1167, 2023 04.

Article en En | MEDLINE | ID: mdl-36478100

Asunto(s)

Analgesia; Nociceptores; Ratones; Animales; Nociceptores/metabolismo; Hiperalgesia/metabolismo; Receptores Opioides mu/metabolismo; Analgésicos Opioides/farmacología; Factor de Crecimiento Nervioso/metabolismo; Calcio/metabolismo; Dinoprostona/metabolismo; Dolor/metabolismo; Péptidos Opioides/metabolismo; Canales Catiónicos TRPV/metabolismo; Ganglios Espinales/metabolismo; Receptor Sigma-1

Palabras clave

Sigma-1 receptors; TRPV1; endomorphin-2; resiniferatoxin; µ-opioid receptors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nociceptores / Analgesia Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido

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