Chemical Stability Study of H<sub>1</sub> Antihistaminic Drugs from the First and the Second Generations, Diphenhydramine, Azelastine and Bepotastine, in Pure APIs and in the Presence of Two Excipients, Citric Acid and Polyvinyl Alcohol.

Gumieniczek, Anna; Lejwoda, Karolina; Data, Natalia

Chemical Stability Study of H₁ Antihistaminic Drugs from the First and the Second Generations, Diphenhydramine, Azelastine and Bepotastine, in Pure APIs and in the Presence of Two Excipients, Citric Acid and Polyvinyl Alcohol.

Gumieniczek, Anna; Lejwoda, Karolina; Data, Natalia.

Afiliación

Gumieniczek A; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Lejwoda K; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Data N; Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.

Molecules ; 27(23)2022 Nov 29.

Article en En | MEDLINE | ID: mdl-36500415

Asunto(s)

Excipientes; Alcohol Polivinílico; Excipientes/química; Estabilidad de Medicamentos; Difenhidramina; Ácido Cítrico; Antagonistas de los Receptores Histamínicos

Palabras clave

FT-IR and NIR; H1 antihistamines; HPLC; UV/VIS light; degradation in solutions and solids; high temperature and high humidity; kinetics of degradation; pH and excipients

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcohol Polivinílico / Excipientes Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza

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