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The Approach to Performance of Quality Upper Endoscopy in Lynch Syndrome (QUELS): An International Expert Statement.
Farha, Natalie; Kumar, Shria; Katona, Bryson W; Hüneburg, Robert; Lynch, Patrick M; Gupta, Samir; Burke, Carol A.
Afiliación
  • Farha N; Departments of Gastroenterology, Hepatology, and Nutrition.
  • Kumar S; Division of Digestive Health and Liver Diseases at the Miller School of Medicine, University of Miami, Miami, FL.
  • Katona BW; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Hüneburg R; Department of Internal Medicine I.
  • Lynch PM; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
  • Gupta S; Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Burke CA; GI section, VA San Diego Healthcare System.
J Clin Gastroenterol ; 57(1): 31-38, 2023 Jan 01.
Article en En | MEDLINE | ID: mdl-36504228
ABSTRACT
Strong evidence demonstrates the protective benefit of frequent colonoscopy surveillance for colorectal cancer prevention in Lynch Syndrome (LS) and is endorsed by many guidelines. Until recently, the evidence supporting the utility of upper endoscopy [esophagogastroduodenoscopy (EGD)] for upper gastrointestinal (UGI) cancer surveillance was limited. Over the last 3 years, multiple studies have demonstrated that EGD surveillance in LS is associated with the detection of both precancerous lesions and early-stage UGI cancers. On the basis of the emerging favorable evidence derived from EGD surveillance programs, the 2022 National Comprehensive Cancer Network (NCCN) Guidelines for LS recommend UGI surveillance with EGD starting between age 30 and 40 years with repeat EGDs every 2 to 4 years, preferably in conjunction with colonoscopy, in all patients with a germline pathogenic variant (PV) in MLH1, MSH2, EPCAM, and MSH6 and, because of the lack of data, consideration in PMS2. Standardization of the approach to performing EGD surveillance in LS and reporting clinically actionable findings is requisite for both improving quality and understanding the cost efficiency and outcomes of patients undergoing EGD as a surveillance tool. Accordingly, the primary objective of this Quality of Upper Endoscopy in Lynch Syndrome (QUELS) statement is to articulate a framework for standardizing the approach to performing and reporting EGD findings in patients with LS by introducing emerging quality metrics. The recommendations presented herein were developed from available evidence and consensus-based expert opinion and provide a practical approach for clinicians applying EGD surveillance in accordance with the most recent and existing LS guidelines.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Colorrectales Hereditarias sin Poliposis Tipo de estudio: Diagnostic_studies / Guideline Límite: Adult / Humans Idioma: En Revista: J Clin Gastroenterol Año: 2023 Tipo del documento: Article Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Neoplasias Colorrectales Hereditarias sin Poliposis Tipo de estudio: Diagnostic_studies / Guideline Límite: Adult / Humans Idioma: En Revista: J Clin Gastroenterol Año: 2023 Tipo del documento: Article Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA