Risk of primary haematologic cancers following incident non-metastatic breast cancer: A Danish population-based cohort study.
Cancer Epidemiol
; 82: 102311, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36508968
ABSTRACT
BACKGROUND:
Breast cancer survivors may have increased risk of subsequent haematologic cancer. We compared their risk of haematologic cancers with the general population during 38 years of follow-up.METHODS:
Using population-based Danish medical registries, we assembled a nationwide cohort of women diagnosed with incident non-metastatic breast cancer during 1980-2017, with follow-up through 2018. We compared breast cancer survivors with the general population by computing standardised incidence ratios (SIR) and 95% confidence intervals (CI).RESULTS:
Among 101,117 breast cancer survivors, we observed 815 incident haematologic cancers (median follow-up 7.9 years). We observed excess risk of acute myeloid leukaemia (AML) (SIR 1.65, 95%CI 1.33-2.01), particularly in women who received chemotherapy (SIR 3.33, 95%CI 2.24-4.75) and premenopausal women (SIR 3.23, 95%CI 2.41-4.25). The risk of acute lymphoid leukaemia (ALL) was increased (SIR 2.25, 95%CI 1.29-3.66), whereas the risk of chronic lymphoid leukaemia (CLL) was decreased (SIR 0.66, 95%CI 0.53-0.82). An additional analysis showed elevated risk of CLL 0-6 months after breast cancer diagnosis (SIR 3.00 95%CI 1.75-4.80).CONCLUSION:
Compared to the general population, breast cancer survivors had elevated risk of AML, particularly when treated with chemotherapy. The risk of ALL was elevated, whereas the risk of CLL was lower. The higher risk of CLL in the first six months after diagnosis likely reflects surveillance bias-due to intensified diagnostic efforts at breast cancer diagnosis and treatment-prompting earlier detection. This has likely reduced the long-term risk of CLL in breast cancer survivors.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Leucemia Linfocítica Crónica de Células B
/
Leucemia Mieloide Aguda
/
Neoplasias Primarias Secundarias
/
Neoplasias Hematológicas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Cancer Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2023
Tipo del documento:
Article