Characteristics of patients with positional OSA according to ethnicity and the identification of a novel phenotype-lateral positional patients: a Multi-Ethnic Study of Atherosclerosis (MESA) study.
J Clin Sleep Med
; 19(3): 529-538, 2023 03 01.
Article
en En
| MEDLINE
| ID: mdl-36533408
ABSTRACT
STUDY OBJECTIVES:
We investigated the characteristics of obstructive sleep apnea (OSA) positional patients' (PP) phenotypes among different ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA) dataset. Moreover, we hypothesized the existence of a new OSA PP phenotype we coined "Lateral PP," for whom the lateral apnea-hypopnea index is at least double the supine apnea-hypopnea index.METHODS:
From 2,273 adults with sleep information, we analyzed data of 1,323 participants who slept more than 4 hours and had at least 30 minutes of sleep in both the supine and the nonsupine positions. Demographics and clinical information were compared for the different PP and ethnic groups.RESULTS:
861 (65.1%) patients had OSA, and 35 (4.1%) were Lateral PP. Lateral PP patients were mainly females (62.9%), obese (median body mass index 31.4 kg/m2), had mild-moderate OSA (94.3%), and mostly were non-Chinese American (97.1%). Among all patients with OSA, 550 (63.9%) were Supine PP and 17.7% were supine-isolated OSA. Supine PP and Lateral PP were present in 73.1% and 1.0% of Chinese Americans, 61.0% and 3.4% of Hispanics, 68.3% and 4.7% of White/Caucasian, and 56.2% and 5.2% of Black/African-American patients with OSA.CONCLUSIONS:
Chinese Americans have the highest prevalence of Supine PP, whereas Black/African-American patients lean toward less Supine PP and higher Lateral PP. Lateral PP appears to be a novel OSA phenotype. However, Lateral PP was observed in a small group of patients with OSA and thus its existence should be further validated. CITATION Ben Sason Y, Oksenberg A, Sobel JA, Behar JA. Characteristics of patients with positional OSA according to ethnicity and the identification of a novel phenotype-lateral positional patients a Multi-Ethnic Study of Atherosclerosis (MESA) study. J Clin Sleep Med. 2023;19(3)529-538.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Etnicidad
/
Apnea Obstructiva del Sueño
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Sleep Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Israel