ETS Fight Club on Microsatellite Enhancers.
Blood Cancer Discov
; 4(1): 2-4, 2023 01 06.
Article
en En
| MEDLINE
| ID: mdl-36538046
ABSTRACT
In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovichet al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6RUNX1-translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription. See related article by Kodgule, Goldman, Monovich et al., p. 34 (5).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia de Células B
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Linfoma de Burkitt
/
Neoplasias Hematológicas
Límite:
Humans
Idioma:
En
Revista:
Blood Cancer Discov
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia
