Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.

Jones, S Paul; Firth, James D; Wheldon, Mary C; Atobe, Masakazu; Hubbard, Roderick E; Blakemore, David C; De Fusco, Claudia; Lucas, Simon C C; Roughley, Stephen D; Vidler, Lewis R; Whatton, Maria Ann; Woolford, Alison J-A; Wrigley, Gail L; O'Brien, Peter

Jones, S Paul; Firth, James D; Wheldon, Mary C; Atobe, Masakazu; Hubbard, Roderick E; Blakemore, David C; De Fusco, Claudia; Lucas, Simon C C; Roughley, Stephen D; Vidler, Lewis R; Whatton, Maria Ann; Woolford, Alison J-A; Wrigley, Gail L; O'Brien, Peter.

Afiliación

Jones SP; Department of Chemistry, University of York Heslington York YO10 5DD UK peter.obrien@york.ac.uk.
Firth JD; Department of Chemistry, University of York Heslington York YO10 5DD UK peter.obrien@york.ac.uk.
Wheldon MC; Department of Chemistry, University of York Heslington York YO10 5DD UK peter.obrien@york.ac.uk.
Atobe M; Department of Chemistry, University of York Heslington York YO10 5DD UK peter.obrien@york.ac.uk.
Hubbard RE; Asahi Kasei Pharma Corporation 632-1 Mifuku, Izunokuni Shizuoka 410-2321 Japan.
Blakemore DC; Department of Chemistry, University of York Heslington York YO10 5DD UK peter.obrien@york.ac.uk.
De Fusco C; Vernalis (R&D) Ltd. Granta Park, Abington Cambridge CB21 6GB UK.
Lucas SCC; Medicine Design, Pfizer Inc. 445 Eastern Point Road Groton CT 06340 USA.
Roughley SD; Bayer AG, Research and Development, Pharmaceuticals, Synthetic Modalities 13353 Berlin Germany.
Vidler LR; Hit Discovery, Discovery Sciences, R&D, AstraZeneca Cambridge CB4 0WG UK.
Whatton MA; Vernalis (R&D) Ltd. Granta Park, Abington Cambridge CB21 6GB UK.
Woolford AJ; Amphista Therapeutics The Cori Building, Granta Park, Great Abington Cambridge CB21 6GQ UK.
Wrigley GL; Evotec (UK) Ltd Dorothy Crowfoot Hodgkin Campus, 114 Innovation Drive, Milton Park, Abingdon Oxon OX14 4RZ UK.
O'Brien P; Astex Pharmaceuticals 436 Cambridge Science Park, Milton Road Cambridge CB4 0QA UK.

RSC Med Chem ; 13(12): 1614-1620, 2022 Dec 14.

Article en En | MEDLINE | ID: mdl-36545433

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Med Chem Año: 2022 Tipo del documento: Article