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Altered mRNA Expression of NFKB1 and NFKB2 Genes in Penile Lichen Sclerosus, Penile Cancer and Zoon Balanitis.
Wierzbicki, Piotr M; Czajkowski, Mateusz; Kotulak-Chrzaszcz, Anna; Bukowicz, Justyna; Dzieciuch, Klaudia; Sokolowska-Wojdylo, Malgorzata; Kmiec, Zbigniew; Matuszewski, Marcin.
Afiliación
  • Wierzbicki PM; Department of Histology, Medical University of Gdansk, 80-211 Gdansk, Poland.
  • Czajkowski M; Department of Urology, Medical University of Gdansk, Mariana Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
  • Kotulak-Chrzaszcz A; Department of Histology, Medical University of Gdansk, 80-211 Gdansk, Poland.
  • Bukowicz J; Hematology Laboratory, Medical University of Gdansk, Mariana Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
  • Dzieciuch K; Early Phase Clinical Research Center, Medical University of Gdansk, Mariana Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
  • Sokolowska-Wojdylo M; Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Mariana Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
  • Kmiec Z; Department of Histology, Medical University of Gdansk, 80-211 Gdansk, Poland.
  • Matuszewski M; Department of Urology, Medical University of Gdansk, Mariana Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
J Clin Med ; 11(24)2022 Dec 07.
Article en En | MEDLINE | ID: mdl-36555871
BACKGROUND: The nuclear factor-κB transcription factors 1 and 2 (NFKB1 and NFKB2) are key components of the NF-κB pathway, which responds to inflammatory signals. Since the NFKB1/2 factors are activated via different inflammatory molecules, we aimed to check their expression levels in penile cancer (PC), penile dermatoses: lichen sclerosus (PLS) and zoon balanitis (ZB). METHODS: Skin biopsies from altered and healthy looking foreskin were obtained from 59 (49 LS; early PLS: 13, moderate PLS: 32, severe PLS: 4; 6 PC; 4 ZB) and unchanged foreskin from 13 healthy control adult males undergoing circumcision. NFKB1/2 mRNA levels were quantified by qPCR. RESULTS: The highest levels of NFKB1 and NFKB2 were observed in PC, ca. 22 and 3.5 times higher than in control, respectively. NFKB1 expression was correlated with PLS progression (rs = 0.667) and was ca. 20 times higher in advanced PLS than in controls and early PLS. Occurrence of micro-incontinence was associated with elevated NFKB1 levels in PLS. CONCLUSION: This is the first study regarding gene profiles of NFKB1/2 in PC and penile dermatoses. New drugs targeting modulation of canonical-activated NF-κB pathway should be studied and introduced to the treatment of PLS and PC apart from other treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2022 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza