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Primary Leptomeningeal Medulloblastoma in Adults: A Diagnostic Challenge-Case Report and Systematic Review.
Fabbro, Sara; Pegolo, Enrico; Piccolo, Daniele; Cramaro, Antonio; Mascarin, Maurizio; Coassin, Elisa; Skrap, Miran; Tuniz, Francesco.
Afiliación
  • Fabbro S; Department of Neurosurgery, ASUFC "Santa Maria della Misericordia," Piazzale Santa Maria della Misericordia, Udine (UD), Italy.
  • Pegolo E; Institute of Anatomic Pathology, ASUFC "Santa Maria della Misericordia," Udine, Italy.
  • Piccolo D; Department of Neurosurgery, ASUFC "Santa Maria della Misericordia," Piazzale Santa Maria della Misericordia, Udine (UD), Italy.
  • Cramaro A; Department of Neurosurgery, ASUFC "Santa Maria della Misericordia," Piazzale Santa Maria della Misericordia, Udine (UD), Italy.
  • Mascarin M; AYA Oncology and Pediatric Radiotherapy Unit, CRO IRCCS, Via Franco Gallini 2, Aviano (PN), Italy.
  • Coassin E; AYA Oncology and Pediatric Radiotherapy Unit, CRO IRCCS, Via Franco Gallini 2, Aviano (PN), Italy.
  • Skrap M; Department of Neurosurgery, ASUFC "Santa Maria della Misericordia," Piazzale Santa Maria della Misericordia, Udine (UD), Italy.
  • Tuniz F; Department of Neurosurgery, ASUFC "Santa Maria della Misericordia," Piazzale Santa Maria della Misericordia, Udine (UD), Italy.
Asian J Neurosurg ; 17(4): 651-655, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36570761
Primary leptomeningeal medulloblastoma (PL-MB) in adults is a rare disease with a severe prognosis. A 35-year-old woman presented with headaches, diplopia, and gait ataxia, with triventricular hydrocephalus and descent of the cerebellar tonsils beyond the foramen magnum. Endoscopic third ventriculostomy was performed. Six months later, headaches recurred. Dilatation of the supratentorial ventricular system and massive cerebellar swelling without contrast-enhancing nodularities were reported. Occipitocervical decompression with duraplasty was performed. A bioptic diagnosis of PL-MB was made. Craniospinal irradiation and chemotherapy were administered. After 18 months, no recurrence was observed. Few cases of PL-MB have been reported: patients die before treatment or within a few days after surgery. Our long-term survival could be ascribable to a slow clinical presentation and an early diagnosis that allowed surgical treatment and the administration of a combined chemoradiotherapy protocol. Cerebellar swelling, even without associated enhancing lesions, with or without hydrocephalus, should be a neuroradiological alarm sign, and PL-MB should be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies / Systematic_reviews Idioma: En Revista: Asian J Neurosurg Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies / Systematic_reviews Idioma: En Revista: Asian J Neurosurg Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: India