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Association between disease-modifying antirheumatic drugs and bone turnover biomarkers.
Azadeh, Hossein.
Afiliación
  • Azadeh H; Department of Internal Medicine, Rheumatology Division, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Rheum Dis ; 26(3): 437-445, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36573666
Rheumatoid arthritis (RA) has been linked to an increased risk of osteoporosis as well as fractures. Patients diagnosed with RA had a 25% increased risk of osteoporotic fracture, according to a recent population-based cohort study that compared them to people without RA. Several studies have found a correlation between osteoporosis and the presence of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and 6. These cytokines play a crucial part in the process of bone resorption by boosting osteoclast activation and encouraging osteoclast differentiation. Based on the correlation between RA, osteoporosis, and inflammation, it is possible that systemic immunosuppression with disease-modifying antirheumatic drugs (DMARDs) can help individuals with RA have a lower chance of developing osteoporosis and osteoporotic fractures. There is little information on how different DMARDs, biologic or non-biologic, affect RA patients' bone metabolism. In this study, we present an overview of the influence that targeted therapies, such as biologics, non-biologics, and small molecule inhibitors, have on bone homeostasis in RA patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Artritis Reumatoide / Antirreumáticos / Fracturas Osteoporóticas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Artritis Reumatoide / Antirreumáticos / Fracturas Osteoporóticas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido