Discrete Orientations of Interfacial Waters Direct Crystallization of Mica-Binding Proteins.
J Phys Chem Lett
; 14(1): 80-87, 2023 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-36573690
ABSTRACT
Understanding the basis of templated molecular assembly on a solid surface requires a fundamental comprehension of both short- and long-range aqueous response to the surface under a variety of solution conditions. Herein we provide a detailed picture of how the molecular-scale response to different mica surfaces yields distinct solvent orientations that produce quasi-static directional potentials onto which macromolecules can adsorb. We connect this directionality to observed (a)symmetric epitaxial alignment of designed proteins onto these surfaces, corroborate our findings with 3D atomic force microscopy experiments, and identify slight differences in surface structure as the origin of this effect. Our work provides a detailed picture of the intrinsic electrolyte response in the vicinity of mineral interfaces, with clear predictions for experiment, and highlights the role of solvent on the predictive assembly of hierarchical materials on mineral surfaces.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Minerales
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Phys Chem Lett
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos