Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.
Biomed J
; 46(6): 100576, 2022 Dec 26.
Article
en En
| MEDLINE
| ID: mdl-36581249
ABSTRACT
BACKGROUND:
Altered autonomic modulation, measured by heart rate variability (HRV), has been found to be associated with dementia risk in the elderly. However, long-term follow-up study evaluating the association between autonomic modulation from middle-age and the incidence of dementia has been limited.METHODS:
This retrospective cohort analyzed data from Taiwan's National Health Insurance Database covering the period from 2001 to 2017, with a linkage to citywide health examinations conducted by Tainan Metropolitan City, Taiwan. We included subjects aged 45-64 years. The mean follow-up period was 15.75 ± 3.40 years. The measurements of HRV included resting heart rate, high frequency (HF), low frequency (LF), standard deviation of normal-to-normal R-R intervals (SDNN), ratio between the 30th and 15th R-R interval after standing up from the supine position (30/15 ratio), ratio between the R-R intervals during expiration and inspiration, and the ratio between the high- and low-frequency components (LF/HF). The main study outcome was the incidence of dementia. We performed multivariable Cox proportional hazard regression models to compare the risk of dementia among different HRV subgroups.RESULTS:
We included 565 participants with a mean age of 53 (SD 6) years, of whom 44% were male. The risk of dementia was significantly increased in association with lower parasympathetic HRV modulation, including SDNN (HR 3.23, 95% CI 1.55-6.73) and 30/15 ratio (HR 3.52, 95%CI 1.67-7.42). Moreover, the risk of dementia was increased in subjects with higher LF/HF ratios (HR 2.05, 95% CI 1.12-3.72).CONCLUSIONS:
Lower parasympathetic activity and higher sympathetic-vagal imbalance in middle-age were associated with dementia risk.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Biomed J
Año:
2022
Tipo del documento:
Article
País de afiliación:
Taiwán