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Experimental models for ageing research.
Toniolo, Luana; Sirago, Giuseppe; Giacomello, Emiliana.
Afiliación
  • Toniolo L; Laboratory of Muscle Biophysics, Department of Biomedical Sciences, University of Padova, Padova, Italy. luana.toniolo@unipd.it.
  • Sirago G; Laboratory of Muscle Biophysics, Department of Biomedical Sciences, University of Padova, Padova, Italy.
  • Giacomello E; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. egiacomello@units.it.
Histol Histopathol ; 38(6): 597-605, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36602135
ABSTRACT
Ageing is a biological process caused by the malfunctioning of multiple cellular mechanisms, ascribable to nine hallmarks genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. These ageing pillars have three common traits (i) they appear during normal ageing; (ii) their experimental intensification accelerates ageing; and (iii) their experimental reduction delays ageing. The evidence that the elderly are more prone to develop pathologies such as cancer, diabetes and degenerative diseases, together with data showing that the elderly population is steadily increasing, has stimulated an important effort to find specific countermeasures to physiological ageing. Unfortunately, the investigation of ageing processes and the search for countermeasures in humans is very difficult. Therefore, researchers must rely on a wide range of experimental models that span from unicellular to more complex organisms. Unfortunately, experimental models are not devoid of pitfalls, flaws or obstacles that can have an impact in ageing research. In the present review we describe the most exploited experimental models in the field, such as in vitro, animal and human models, highlighting the characteristics that justify their application in the laboratory routine, and translation to human research.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Senescencia Celular Tipo de estudio: Prognostic_studies Límite: Aged / Animals / Humans Idioma: En Revista: Histol Histopathol Asunto de la revista: HISTOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Senescencia Celular Tipo de estudio: Prognostic_studies Límite: Aged / Animals / Humans Idioma: En Revista: Histol Histopathol Asunto de la revista: HISTOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia