Global Analysis of <i>Plasmodium falciparum</i> Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.

Boateng, Rita Afriyie; Myers-Hansen, James L; Dolling, Nigel N O; Mensah, Benedicta A; Brodsky, Elia; Mazumder, Mohit; Ghansah, Anita

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.

Boateng, Rita Afriyie; Myers-Hansen, James L; Dolling, Nigel N O; Mensah, Benedicta A; Brodsky, Elia; Mazumder, Mohit; Ghansah, Anita.

Afiliación

Boateng RA; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Myers-Hansen JL; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Dolling NNO; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Mensah BA; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Brodsky E; Pine Biotech, Inc., 1441 Canal St., New Orleans, LA 70112, USA.
Mazumder M; Pine Biotech, Inc., 1441 Canal St., New Orleans, LA 70112, USA.
Ghansah A; Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.

Molecules ; 28(1)2022 Dec 24.

Article en En | MEDLINE | ID: mdl-36615340

Asunto(s)

Antimaláricos; Dihidropteroato Sintasa; Malaria Falciparum; Plasmodium falciparum; Niño; Femenino; Humanos; Embarazo; Antimaláricos/farmacología; Antimaláricos/uso terapéutico; Dihidropteroato Sintasa/genética; Combinación de Medicamentos; Resistencia a Medicamentos/genética; Malaria Falciparum/tratamiento farmacológico; Malaria Falciparum/genética; Simulación del Acoplamiento Molecular; Mutación; Sulfadoxina/farmacología; Sulfadoxina/uso terapéutico; Tetrahidrofolato Deshidrogenasa/genética

Palabras clave

Pfdhps; haplotype; malaria; molecular docking; molecular dynamics simulations; mutations; sulfadoxine resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Malaria Falciparum / Dihidropteroato Sintasa / Antimaláricos Tipo de estudio: Risk_factors_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Suiza

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