Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase.

Tong, Huawei; Wang, Xuchen; Liu, Yuanhua; Liu, Nana; Li, Yun; Luo, Jiamin; Ma, Qian; Wu, Danni; Li, Jiyong; Xu, Chunlong; Yang, Hui

Tong, Huawei; Wang, Xuchen; Liu, Yuanhua; Liu, Nana; Li, Yun; Luo, Jiamin; Ma, Qian; Wu, Danni; Li, Jiyong; Xu, Chunlong; Yang, Hui.

Afiliación

Tong H; HuiGene Therapeutics Co., Ltd., Shanghai, China. huaweitong@huidagene.com.
Wang X; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Liu Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Liu N; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Li Y; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Luo J; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Ma Q; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Wu D; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Li J; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Xu C; HuiGene Therapeutics Co., Ltd., Shanghai, China.
Yang H; Lingang Laboratory, Shanghai, China. xucl@lglab.ac.cn.

Nat Biotechnol ; 41(8): 1080-1084, 2023 08.

Article en En | MEDLINE | ID: mdl-36624150

Asunto(s)

Adenina; ADN Glicosilasas; Animales; Adenina/metabolismo; Edición Génica; Reparación del ADN/genética; ADN Glicosilasas/genética; ADN Glicosilasas/metabolismo; Mamíferos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenina / ADN Glicosilasas Límite: Animals Idioma: En Revista: Nat Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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