Association between CYP19A1 rs6493497 and rs936306 polymorphisms and depression susceptibility in the Chinese population.
Biomark Med
; 16(16): 1171-1179, 2022 11.
Article
en En
| MEDLINE
| ID: mdl-36628958
The cause of depression is complex and not fully elucidated; the research evidence suggests that changes in estrogen levels may partly account for the risk of the onset of depression. The CYP19A1 gene encodes the key enzyme for estrogen biosynthesis, and this study aimed to explore whether the two loci (rs6493497 and rs936306) variants of the CYP19A1 gene are associated with the risk of occurrence of depression. Five hundred two patients with depression and 504 healthy controls were enrolled. The results of this study indicate that the CYP19A1 gene rs936306 variant may reduce the risk of occurrence of depression, and the rs6493497 variant is associated with decreased depression risk in men aged 4665.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aromatasa
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Biomark Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Reino Unido