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Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.
Shih, Nien-Chu; Kurniawan, Nyoman D; Cabeen, Ryan P; Korobkova, Laura; Wong, Ellen; Chui, Helena C; Clark, Kristi A; Miller, Carol A; Hawes, Debra; Jones, Kymry T; Sepehrband, Farshid.
Afiliación
  • Shih NC; USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Kurniawan ND; Center for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia.
  • Cabeen RP; USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Korobkova L; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089. USA.
  • Wong E; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA.
  • Chui HC; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Clark KA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Miller CA; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Hawes D; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Los Angeles, Los Angeles, CA 90033, USA.
  • Jones KT; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: KTJONE8@emory.edu.
  • Sepehrband F; USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: Farshid.sepehrband@loni.usc.edu.
Neuroimage Clin ; 37: 103318, 2023.
Article en En | MEDLINE | ID: mdl-36630864
ABSTRACT
The dentate gyrus (DG) is an integral portion of the hippocampal formation, and it is composed of three layers. Quantitative magnetic resonance (MR) imaging has the capability to map brain tissue microstructural properties which can be exploited to investigate neurodegeneration in Alzheimer's disease (AD). However, assessing subtle pathological changes within layers requires high resolution imaging and histological validation. In this study, we utilized a 16.4 Tesla scanner to acquire ex vivo multi-parameter quantitative MRI measures in human specimens across the layers of the DG. Using quantitative diffusion tensor imaging (DTI) and multi-parameter MR measurements acquired from AD (N = 4) and cognitively normal control (N = 6) tissues, we performed correlation analyses with histological measurements. Here, we found that quantitative MRI measures were significantly correlated with neurofilament and phosphorylated Tau density, suggesting sensitivity to layer-specific changes in the DG of AD tissues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos