Residual dynamics resolves recurrent contributions to neural computation.
Nat Neurosci
; 26(2): 326-338, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36635498
ABSTRACT
Relating neural activity to behavior requires an understanding of how neural computations arise from the coordinated dynamics of distributed, recurrently connected neural populations. However, inferring the nature of recurrent dynamics from partial recordings of a neural circuit presents considerable challenges. Here we show that some of these challenges can be overcome by a fine-grained analysis of the dynamics of neural residuals-that is, trial-by-trial variability around the mean neural population trajectory for a given task condition. Residual dynamics in macaque prefrontal cortex (PFC) in a saccade-based perceptual decision-making task reveals recurrent dynamics that is time dependent, but consistently stable, and suggests that pronounced rotational structure in PFC trajectories during saccades is driven by inputs from upstream areas. The properties of residual dynamics restrict the possible contributions of PFC to decision-making and saccade generation and suggest a path toward fully characterizing distributed neural computations with large-scale neural recordings and targeted causal perturbations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimientos Sacádicos
/
Corteza Prefrontal
Límite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Suiza