Association between Serum α-Klotho Levels and Behçet Disease.
Lab Med
; 54(5): 469-472, 2023 Sep 05.
Article
en En
| MEDLINE
| ID: mdl-36637200
ABSTRACT
BACKGROUND:
Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.OBJECTIVE:
To assess serum α-klotho in patients with BD, compared with healthy control individuals.METHODS:
In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.RESULTS:
Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (Pâ =â .005). No significant correlation was observed between serum α-klotho and age (râ =â 0.194; Pâ =â .14). Serum α-klotho levels in patients with uveitis were significantly lower.CONCLUSION:
α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uveítis
/
Síndrome de Behçet
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Lab Med
Año:
2023
Tipo del documento:
Article