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Preliminary Experience Suggests the Addition of Choroid Plexus Cauterization to Functional Hemispherectomy May Reduce Posthemispherectomy Hydrocephalus.
Phillips, H Westley; Chen, Jia-Shu; Tucker, Alexander M; Ding, Kevin; Kashanian, Alon; Nagahama, Yasunori; Mathern, Gary W; Weil, Alexander G; Fallah, Aria.
Afiliación
  • Phillips HW; Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
  • Chen JS; The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Tucker AM; Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Ding K; Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
  • Kashanian A; Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
  • Nagahama Y; Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
  • Mathern GW; Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
  • Weil AG; The Intellectual Disabilities and Developmental Research Center, Department of Psychiatry and Biobehavioral Medicine, University of California, Los Angeles, Los Angeles, California, USA.
  • Fallah A; Department of Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Neurosurgery ; 92(2): 300-307, 2023 02 01.
Article en En | MEDLINE | ID: mdl-36637266
BACKGROUND: Cerebral hemispherectomy can effectively treat unihemispheric epilepsy. However, posthemispherectomy hydrocephalus (PHH), a serious life-long complication, remains prevalent, requiring careful considerations in technique selection and postoperative management. In 2016, we began incorporating open choroid plexus cauterization (CPC) into our institution's hemispherectomy procedure in an attempt to prevent PHH. OBJECTIVE: To determine whether routine CPC prevented PHH without exacerbating hemispherectomy efficacy or safety. METHODS: A retrospective review of consecutive patients who underwent hemispherectomy for intractable epilepsy between 2011 and 2021 was performed. Multivariate logistic regression was used to identify factors independently associated with PHH requiring cerebrospinal fluid (CSF) shunting. RESULTS: Sixty-eight patients were included in this study, of whom 26 (38.2%) underwent CPC. Fewer patients required CSF shunting in the CPC group (7.7% vs 28.7%, P = .033) and no patients who underwent de novo hemispherectomy with CPC developed PHH. Both cohorts experienced seizure freedom (65.4% vs 59.5%, P = .634) and postoperative complications, including infection (3.8% vs 2.4%, P = .728), hemorrhage (0.0% vs 2.4%, P = .428), and revision hemispherectomy (19.2% vs 14.3%, P = .591) at similar rates. Patients without CPC had greater odds of developing PHH requiring CSF shunting (odds ratio = 8.36, P = .026). The number needed to treat with CPC to prevent an additional case of PHH was 4.8, suggesting high effectiveness. CONCLUSION: Preventing PHH is critical. Our early experience demonstrated that routinely incorporating CPC into hemispherectomy effectively prevents PHH without causing additional complications, especially in first-time hemispherectomies. A multicenter randomized controlled trial with long-term follow-up is required to corroborate the findings of our single-institutional case series and determine whether greater adoption of this technique is justified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemisferectomía / Hidrocefalia Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies Límite: Humans / Infant Idioma: En Revista: Neurosurgery Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemisferectomía / Hidrocefalia Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies Límite: Humans / Infant Idioma: En Revista: Neurosurgery Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos