Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity.

Li, Fen; Li, Dongsheng; Liu, Jianguang; Tang, Shifan; Yan, Jie; Li, Hongwei; Wan, Zhengyun; Wang, Lian; Yan, Xisheng

Li, Fen; Li, Dongsheng; Liu, Jianguang; Tang, Shifan; Yan, Jie; Li, Hongwei; Wan, Zhengyun; Wang, Lian; Yan, Xisheng.

Afiliación

Li F; Department of Neurology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Li D; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Liu J; Department of Neurology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Tang S; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Yan J; Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Li H; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Wan Z; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Wang L; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Yan X; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address: xishengyan2017@163.com.

J Pain ; 24(7): 1163-1180, 2023 Jul.

Article en En | MEDLINE | ID: mdl-36641029

Asunto(s)

Dolor Crónico; Lupus Eritematoso Sistémico; Ratones; Femenino; Animales; Dolor Crónico/etiología; Dolor Crónico/metabolismo; Hiperalgesia/etiología; Hiperalgesia/metabolismo; Receptor PAR-1/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Sistema de Transporte de Aminoácidos X-AG/metabolismo; Lupus Eritematoso Sistémico/metabolismo; Asta Dorsal de la Médula Espinal/metabolismo; Glutamatos/metabolismo

Palabras clave

Glutamate uptake; MRL lupus-prone; Neuroinflammation; Nociception; Protease-activated receptor-1

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Crónico / Lupus Eritematoso Sistémico Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google