A "middle-out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models.

Yau, Estelle; Gertz, Michael; Ogungbenro, Kayode; Aarons, Leon; Olivares-Morales, Andrés

Yau, Estelle; Gertz, Michael; Ogungbenro, Kayode; Aarons, Leon; Olivares-Morales, Andrés.

Afiliación

Yau E; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.
Gertz M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Ogungbenro K; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Aarons L; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.
Olivares-Morales A; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.

CPT Pharmacometrics Syst Pharmacol ; 12(3): 346-359, 2023 03.

Article en En | MEDLINE | ID: mdl-36647756

Asunto(s)

Diazepam; Midazolam; Humanos; Ratas; Animales; Midazolam/farmacocinética; Diazepam/farmacocinética; Cinética; Modelos Biológicos; Haplorrinos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Midazolam / Diazepam Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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