Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase.
J Transl Med
; 21(1): 31, 2023 01 17.
Article
en En
| MEDLINE
| ID: mdl-36650543
ABSTRACT
NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Histonas
/
Histona Acetiltransferasas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Transl Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
China