Nomogram to predict overall survival in patients with primary bladder neuroendocrine carcinoma: a population-based study.
Future Oncol
; 18(38): 4171-4181, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36651444
ABSTRACT
Aim:
To develop a prognostic model to predict the overall survival of primary bladder neuroendocrine carcinoma (BNEC) patients.Methods:
Using univariate and multivariate Cox regression analyses, a nomogram was constructed. Calibration curves, receiver operating characteristic curves and C-index were utilized to evaluate the performance.Results:
The study enrolled 906 BNEC patients. The following variables were incorporated in the nomogram age, marital status, Tumor node metastasis (TNM) stage, chemotherapy and surgery. The nomogram had a C-index of 0.702 in the training cohort and 0.724 in the validation cohort.Conclusion:
Compared with the TNM staging system, the proposed nomogram exhibits superior prognostic discrimination and survival prediction.
Neuroendocrine bladder cancer accounts for <1% of all bladder cancers and has a poor prognosis. Due to its rarity, the best treatment still requires further exploration. A total of 906 patients with neuroendocrine bladder cancer were recruited from the SEER database. The three- and five-year survival rates were <40%. Combination therapy results in longer survival compared with a single therapy. Patients are advised to receive comprehensive treatment if their physical condition is tolerable. An accurate, easy-to-understand nomogram to predict overall survival in patients with neuroendocrine bladder cancer was developed. The nomogram will enable clinicians to assess a patient's risk and apply personalized treatment.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Carcinoma Neuroendocrino
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Future Oncol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China