Early-life risk factors for development of asthma from 8 to 28â
years of age: a prospective cohort study.
ERJ Open Res
; 8(4)2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-36655222
ABSTRACT
Background:
The objective was to estimate the incidence rate of asthma from age 8 to 28â years and evaluate early-life risk factors for asthma onset at different ages.Methods:
In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8â years to a prospective study about asthma. The cohort was followed annually from age 8 to 19â years and at 28â years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ≤8â years, onset age 9-13â years, onset age 14-19â years or onset age >19â years.Results:
Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ≤8â years, 11.9/1000 per year at 9-13â years, 13.3/1000 per year at 14-19â years and 6.1/1000 per year at >19â years. The incidence was higher among boys until age 10â years, but from age 15â years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3â months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ≤8 and 9-13â years.Conclusions:
The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
ERJ Open Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Suecia