Your browser doesn't support javascript.
loading
3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases.
Cuní-López, Carla; Stewart, Romal; White, Anthony R; Quek, Hazel.
Afiliación
  • Cuní-López C; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; Faculty of Medicine, The University of Queensland, Brisbane 4006, QLD, Australia. Electronic address: Carla.Cuni-Lopez@qimrberghofer.edu.au.
  • Stewart R; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; UQ Centre for Clinical Research, The University of Queensland, Brisbane 4006, QLD, Australia. Electronic address: Romal.Stewart@qimrberghofer.edu.au.
  • White AR; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; School of Biomedical Science, The University of Queensland, Brisbane 4072, QLD, Australia. Electronic address: Tony.White@qimrberghofer.edu.au.
  • Quek H; Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia; School of Biomedical Science, The University of Queensland, Brisbane 4072, QLD, Australia; School of Biomedical Science, Queensland University of Technology, Brisbane 4059, QLD, Australia. Elect
J Neuroimmunol ; 375: 578017, 2023 02 15.
Article en En | MEDLINE | ID: mdl-36657374
Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the development of microglia-targeted therapeutics for neurodegeneration has had limited success. This stems partly from the lack of clinically relevant microglia model systems. To circumvent this translational gap, patient-derived microglial cell models established using conventional 2D in vitro techniques have emerged. Though promising, these models lack the microenvironment and multicellular interactions of the brain needed to maintain microglial homeostasis. In this review, we discuss the use of 3D in vitro platforms to improve microglia modelling and their potential benefits to fast-track drug development for neurodegenerative diseases.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Enfermedades Neurodegenerativas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Enfermedades Neurodegenerativas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos