Approche thérapeutique des maladies de Castleman : l'émergence des thérapies ciblées.
Rev Med Interne
; 43(10S1): 10S26-10S33, 2022 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-36657940
ABSTRACT
The spectrum of Castleman disease encompasses several different disorders. Nowadays three different forms of the disease are individualized unicentric Castleman disease, multicentric HHV-8 associated Castleman disease and idiopathic multicentric Castleman disease. In the latter a severe form called TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly) tend to be individualized. Improvement in the classification and understanding of the physiopathology of CD have allowed improvement in treatment strategies. Treatment of rare but often severe manifestations, such as paraneoplastic pemphigus and bronchiolitis obliterans in unicentric CD and hemophagocytic syndrome and/or Kaposi' sarcoma in HHV8 associated CD, are better adapted. Most of current treatment strategies are based on retrospective and very few prospective studies. Both anti-IL6/6R and anti-CD20 biotherapies have greatly improved the management of certain forms of the disease. We report in this review the most relevant studies and national or international expert consensus statements for the treatment in the different types of CD. © 2022 Published by Elsevier Masson SAS on behalf of Société nationale française de médecine interne (SNFMI).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sarcoma de Kaposi
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Enfermedad de Castleman
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Herpesvirus Humano 8
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
Fr
Revista:
Rev Med Interne
Año:
2022
Tipo del documento:
Article
Pais de publicación:
FR
/
FRANCE
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FRANCIA
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FRANÇA