A new phenyl 6,7-dihydroxygeranyl ether derivative from a marine-derived fungus strain of Penicillium arabicum ZH3-9.

ABSTRACT

A new phenyl 6,7-dihydroxygeranyl ether derivative, named (Z)-4-((6,7-dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy)benzoic acid (1), and 8 known compounds (2-9) were characterized from a marine-derived fungus strain of Penicillium arabicum ZH3-9 isolated from a mud sample collected from the coast of Zhuhai, Guangdong Province, China. The structure of 1 was elucidated by HRESIMS, 1 D and 2 D NMR. All compounds were evaluated antimicrobial activities against Candida albicans, Staphylococcus aureus, and Escherichia coli. Compounds 4-6 displayed antibacterial activity against S. aureus with minimum inhibitory concentrations of 50, 12.5, and 50 µg/mL.