Targeting in silico GPCR conformations with ultra-large library screening for hit discovery.

Sala, D; Batebi, H; Ledwitch, K; Hildebrand, P W; Meiler, J

Sala, D; Batebi, H; Ledwitch, K; Hildebrand, P W; Meiler, J.

Afiliación

Sala D; Institute of Drug Discovery, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.
Batebi H; Institute of Medical Physics and Biophysics, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.
Ledwitch K; Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
Hildebrand PW; Institute of Medical Physics and Biophysics, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.
Meiler J; Institute of Drug Discovery, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany; Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: jens@meilerlab.org.

Trends Pharmacol Sci ; 44(3): 150-161, 2023 03.

Article en En | MEDLINE | ID: mdl-36669974

Asunto(s)

Descubrimiento de Drogas; Receptores Acoplados a Proteínas G; Humanos; Receptores Acoplados a Proteínas G/metabolismo; Conformación Proteica; Ligandos

Palabras clave

AlphaFold; GPCR; biased ligands; drug discovery; structure-based drug discovery; ultra-large library

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Descubrimiento de Drogas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Trends Pharmacol Sci Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google