The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis.

Sernoskie, Samantha Christine; Jee, Alison; Uetrecht, Jack

Sernoskie, Samantha Christine; Jee, Alison; Uetrecht, Jack.

Afiliación

Sernoskie SC; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
Jee A; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Uetrecht J; Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.

Int J Mol Sci ; 24(2)2023 Jan 08.

Article en En | MEDLINE | ID: mdl-36674761

Asunto(s)

Antipsicóticos; Clozapina; Neutropenia; Humanos; Ratas; Animales; Clozapina/efectos adversos; Peroxidasa/metabolismo; Ratas Sprague-Dawley; Antipsicóticos/efectos adversos; Inflamación/tratamiento farmacológico; Colorantes; Mediadores de Inflamación

Palabras clave

MPO; Sprague Dawley rats; THP-1 macrophages; clozapine; idiosyncratic drug-induced agranulocytosis; inflammation; myeloperoxidase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Clozapina / Neutropenia Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza

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