A snapshot survey of antimicrobial resistance in food-animals in low and middle-income countries.

ABSTRACT

Antimicrobial resistance remains a threat to global public health. Low-and middle-income countries carry a greater burden of resistance because of higher rates of infection as well as, potentially, location-specific risk factors. Food animals occupy a critical crossover point for the spread of antimicrobial resistance to humans and the environment. However, this domain remains poorly surveilled outside high-income settings. We used point surveillance from 191 studies reporting phenotypic AMR in food animals across 38 African, Middle Eastern, Asian and South and Central American countries to depict antimicrobial resistance trend in food animals. By computing Multiple Antibiotic Resistance indices and finding an overall mean of 0.34 ± 0.16, which is above the 0.2 index associated with multidrug resistance and high risk, we show that multidrug resistance in bacteria from food animal sources is worryingly high. MAR indexes from food animals were overall higher than those previously computed from aquaculture but, unlike aquaculture-computed MAR indices, did not track closely with those of human-associated bacteria in the same countries. Food animals are an important reservoir for rising antimicrobial resistance in bacteria, and hence improved surveillance in this sector is highly recommended.