Association of common genetic variants with body mass index in Russian population.
Eur J Clin Nutr
; 77(5): 574-578, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36690773
ABSTRACT
BACKGROUND:
Overweight is the scourge of modern society and a major risk factor for many diseases. For this reason, understanding the genetic component predisposing to high body mass index (BMI) seems to be an important task along with preventive measures aimed at improving eating behavior and increasing physical activity.METHODS:
We analyzed genetic data of a European cohort (n = 21,080, 47.25% women, East Slavs ancestry >80%) for 5 frequently found genes in the context of association with obesity IPX3 (rs3751723), MC4R (rs17782313), TMEM18 (rs6548238), PPARG (rs1801282) and FTO (rs9939609).RESULTS:
Our study revealed significant associations of FTO (rs9939609) (ß = 0.37 (kg/m2)/allele, p = <2 × 10-16), MC4R (rs17782313) (ß = 0.28 (kg/m2)/allele, p = 5.79 × 10-9), TMEM18 (rs6548238) (ß = 0.29 (kg/m2)/allele, p = 2.43 × 10-8) with BMI and risk of obesity.CONCLUSIONS:
The results confirm the contribution of FTO, M4CR, and TMEM18 genes to the mechanism of body weight regulation and control.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Clin Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2023
Tipo del documento:
Article
País de afiliación:
Rusia