TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma.

Mäki-Opas, Ilari; Hämäläinen, Mari; Moilanen, Eeva; Scotece, Morena

Mäki-Opas, Ilari; Hämäläinen, Mari; Moilanen, Eeva; Scotece, Morena.

Afiliación

Mäki-Opas I; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014, Tampere, Finland. ilari.maki-opas@tuni.fi.
Hämäläinen M; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014, Tampere, Finland.
Moilanen E; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014, Tampere, Finland.
Scotece M; The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014, Tampere, Finland.

Arthritis Res Ther ; 25(1): 12, 2023 01 25.

Article en En | MEDLINE | ID: mdl-36698198

Asunto(s)

Esclerodermia Localizada; Esclerodermia Sistémica; Ratones; Animales; Bleomicina/toxicidad; Activación de Macrófagos; Interleucina-4/efectos adversos; Interleucina-4/metabolismo; Esclerodermia Sistémica/patología; Fibrosis; Colágeno/metabolismo; Esclerodermia Localizada/inducido químicamente; Esclerodermia Localizada/patología; Modelos Animales de Enfermedad; Piel/patología; Canal Catiónico TRPA1/genética

Palabras clave

Autoimmune diseases; Inflammation; Macrophages; Scleroderma; Systemic; TRPA1; Transient receptor potential channels

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerodermia Localizada / Esclerodermia Sistémica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Arthritis Res Ther Asunto de la revista: REUMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido

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