Regiodivergent Metal-Controlled Synthesis of Multiply Substituted Quinolin-2-yl- and Quinolin-3-ylphosphonates.
J Org Chem
; 88(4): 2367-2376, 2023 Feb 17.
Article
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| MEDLINE
| ID: mdl-36700697
ABSTRACT
In this study, we developed a selective method for synthesis of multi-substituted quinoline-2-ylphosphonates and quinoline-3-ylphosphonates by copper- or gold-catalyzed reactions of phosphoryl-substituted conjugated ynones with 2'-amino-2,2,2-trifluoroacetophenones. The approach proposed makes it possible to obtain various substituted quinolines in good yields. It is also shown that (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate reacts with 2-aminoaryl ketones under non-catalytic conditions with formation of 4-substituted quinoline-2-ylphosphonates in high yields.
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Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
J Org Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
Rusia