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Central pontine myelinolysis and locked-IN syndrome associated with tacrolimus after pediatric heart transplantation.
Albert-Brotons, Dimpna C; Alharkan, Waleed; Beheri, Reem; AlHaddad, Mohammed; Alali, Yasser; Alheraish, Yasser; Chedrawi, Aziza; AlHalees, Zohair.
Afiliación
  • Albert-Brotons DC; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • Alharkan W; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • Beheri R; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • AlHaddad M; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • Alali Y; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • Alheraish Y; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • Chedrawi A; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
  • AlHalees Z; King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Pediatr Transplant ; 27(3): e14474, 2023 05.
Article en En | MEDLINE | ID: mdl-36717958
BACKGROUND: Locked-in syndrome represents the most severe form of central pontine myelinolysis and varies in presentation from asymptomatic to fully developed locked-in-syndrome characterized by the combination of quadriplegia, loss of the ability to communicate except through the use of the eyes, and an inability to follow commands. METHODS: We report a 10-year-old boy who developed a severe case of locked-in syndrome after heart transplantation. RESULTS: Patient had a spontaneous recovery, treated with supportive treatment and the improvement was detected with cessation of calcineurin inhibitor therapy by substituting with an mTOR inhibitor (sirolimus). No cases of locked-in syndrome post-heart transplant in pediatrics cases have been documented in the literature. CONCLUSION: Physicians should recognize a rapid progression of central pontine myelinolysis and locked-in syndrome in the context of heart transplant and although several factors likely contributed to this outcome, adjustment of immunosuppression including by substituting tacrolimus with sirolimus could be effective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón / Mielinólisis Pontino Central / Síndrome de Enclaustramiento Tipo de estudio: Risk_factors_studies Límite: Child / Humans / Male Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Dinamarca

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón / Mielinólisis Pontino Central / Síndrome de Enclaustramiento Tipo de estudio: Risk_factors_studies Límite: Child / Humans / Male Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Dinamarca