Enzyme multiplied immunoassay of phenytoin and carbamazepine using the Centrifichem analyser.

ABSTRACT

Procedures for the enzyme multiplied immunoassay of phenytoin and carbamazepine using the Centrifichem centrifugal analyser are described. Within-batch, between-batch, and between-day precision are reported. Accuracy is assessed by recovery experiments. The technique is compared with gas-liquid chromatography in the analysis of a number of human serum samples containing a range of concentrations of the drugs.