RIMeta: An R shiny tool for estimating the reference interval from a meta-analysis.
Res Synth Methods
; 14(3): 468-478, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-36725922
A reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference interval estimated by combining the data across these studies is typically more generalizable than a reference interval based on a single study. Methods for estimating reference intervals from random effects meta-analysis and fixed-effects meta-analysis have been recently proposed and implemented using R software. We present an R Shiny tool, RIMeta, implementing these methods, which allows users not proficient in R to estimate a reference interval from a meta-analysis using aggregate data (mean, standard deviation, and sample size) from each study. RIMeta (https://cers.shinyapps.io/RIMeta/) provides users a convenient way to estimate a reference interval from a meta-analysis and to generate the reference interval plot to visualize the results. The use of this web-based R Shiny tool does not require the installation of R or any background knowledge of programming. We explain all functions of the R Shiny tool and illustrate how to use it with a real data example.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Programas Informáticos
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Res Synth Methods
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido