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Spike Gene Target Amplification in a Diagnostic Assay as a Marker for Public Health Monitoring of Emerging SARS-CoV-2 Variants - United States, November 2021-January 2023.
MMWR Morb Mortal Wkly Rep ; 72(5): 125-127, 2023 Feb 03.
Article en En | MEDLINE | ID: mdl-36730050
ABSTRACT
Monitoring emerging SARS-CoV-2 lineages and their epidemiologic characteristics helps to inform public health decisions regarding vaccine policy, the use of therapeutics, and health care capacity. When the SARS-CoV-2 Alpha variant emerged in late 2020, a spike gene (S-gene) deletion (Δ69-70) in the N-terminal region, which might compensate for immune escape mutations that impair infectivity (1), resulted in reduced or failed S-gene target amplification in certain multitarget reverse transcription-polymerase chain reaction (RT-PCR) assays, a pattern referred to as S-gene target failure (SGTF) (2). The predominant U.S. SARS-CoV-2 lineages have generally alternated between SGTF and S-gene target presence (SGTP), which alongside genomic sequencing, has facilitated early monitoring of emerging variants. During a period when Omicron BA.5-related sublineages (which exhibit SGTF) predominated, an XBB.1.5 sublineage with SGTP has rapidly expanded in the northeastern United States and other regions.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salud Pública / COVID-19 Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: MMWR Morb Mortal Wkly Rep Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salud Pública / COVID-19 Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: MMWR Morb Mortal Wkly Rep Año: 2023 Tipo del documento: Article
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