Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and in vitro evaluation.
Ther Deliv
; 2023 Feb 07.
Article
en En
| MEDLINE
| ID: mdl-36748662
ABSTRACT
Aim:
In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials &methods:
The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer.Results:
SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. In vitro studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles.Conclusion:
Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Ther Deliv
Año:
2023
Tipo del documento:
Article
País de afiliación:
India